Anti-LATS1/2 antibody
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概述
- 产品描述The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
- 产品名称Anti-LATS1/2 antibody
- 分子量130-140 kDa
- 种属反应性Human, Mouse
- 验证应用WB, IHC-P
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human LATS1/2. AA range:1041-1090
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 其它名称LATS1 antibody; WARTS antibody; Serine/threonine-protein kinase LATS1 antibody; Large tumor suppressor homolog 1 antibody; WARTS protein kinase antibody; h-warts antibody; LATS2 antibody; KPM antibody; Serine/threonine-protein kinase LATS2 antibody; Kinase phosphorylated during mitosis protein antibody; Large tumor suppressor ho antibody;
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Fig1: Western Blot analysis of various cells using LATS1/2 Polyclonal Antibody diluted at 1：500
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