Anti-eIF4G antibody
-
概述
- 产品描述Eukaryotic translation initiation factor 4 G (eIF4G) is a protein involved in eukaryotic translation initiation and is a component of the eIF4F cap-binding complex. Orthologs of eIF4G have been studied in multiple species, including humans, yeast, and wheat. However, eIF4G is exclusively found in domain Eukarya, and not in domains Bacteria or Archaea, which do not have capped mRNA. As such, eIF4G structure and function may vary between species, although the human eIF4G 1 has been the focus of extensive studies. Across species, eIF4G strongly associates with eIF4E, the protein that directly binds the mRNA cap. Together with the RNA helicase protein eIF4A, these form the eIF4F complex. Within the cell eIF4G is found primarily in the cytoplasm, usually bound to eIF4E; however, it is also found in the nucleus, where its function is unknown. It may have a role in nonsense-mediated decay. eIF4G has been implicated in breast cancer. It appears in increased levels in certain types of breast cancer and increases production of mRNAs that contain IRESs; these mRNAs produce hypoxia- and stress-related proteins that encourage blood vessel invasion (which is important for tumorigenesis).
- 产品名称Anti-eIF4G antibody
- 分子量175 kDa
- 种属反应性Human, Mouse, Rat
- 验证应用IHC-P, IF, WB
- 抗体类型兔多抗
- 免疫原The antiserum was produced against synthesized peptide derived from human eIF4G. AA range:1074-1123
- 偶联Non-conjugated
-
性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified.
- 亚细胞定位Cytosol. Nucleus.
- 其它名称DKFZp686A1451 antibody
eIF 4 gamma 1 antibody
eIF 4G 1 antibody
eIF 4G1 antibody
eIF-4-gamma 1 antibody
eIF-4G 1 antibody
eIF-4G1 antibody
EIF4 gamma antibody
EIF4F antibody
EIF4G antibody
EIF4G1 antibody
EIF4GI antibody
Eukaryotic translation initiation factor 4 gamma 1 antibody
IF4G1_HUMAN antibody
p220 antibody
more
-
应用
WB: 1:500-1:2000
IHC-P: 1:100-1:300
IF: 1:100-1:500
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
