Anti-MEK Kinase-4 antibody

Anti-MEK Kinase-4 antibody

• 概述

• 产品描述The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6
• 产品名称Anti-MEK Kinase-4 antibody
• 种属反应性Human,Mouse
• 验证应用IHC-P
• 抗体类型兔多抗
• 免疫原The antiserum was produced against synthesized peptide derived from human MAP3K4. AA range:1281-1330
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度1 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• 亚型IgG
• 纯化方式Immunogen affinity purified.
• 其它名称MAP3K4 antibody; KIAA0213 antibody; MAPKKK4 antibody; MEKK4 antibody; MTK1 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MAP three kinase 1 antibody; MAPK/ERK kinase kinase 4 antibody; MEK kinase 4 antibody; MEKK 4 antibody;

• 应用

  IHC-P: 1:100-1:300

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