Anti-LC3A/B antibody
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概述
- 产品描述Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3β) and MAP-light chain 3 alpha (MAP-LC3α) are subunits that can associate with either MAP-1A or MAP-1B. While MAP-LC3β is essential for autophagy and is associated with autophagosome membranes after processing, MAP LC3α is involved in the formation of autophagosomal vacuoles and is localized to the intracytoplasmic membrane. MAP LC3α is expressed as two alternatively spliced isoforms that are expressed in testis, brain, heart, liver and skeletal muscle, but are absent in thymus and peripheral blood leukocytes. MAP LC3β, which exists in a cytosolic and a membrane-bound form, may also be involved in formation of autophagosomal vacuoles and is expressed primarily in heart, testis, brain and skeletal muscle.
- 产品名称Anti-LC3A/B antibody
- 分子量15 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IP,IF
- 抗体类型兔多抗
- 免疫原Amino acids 58-104 mapping within an internal region of MAP LC3α of human origin.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Immunogen affinity purified
- 亚细胞定位Cytoplasm, Cytoplasmic vesicle Endomembrane system
- 其它名称
- ATG8F antibody
- Autophagy related protein LC3 A antibody
- Autophagy related protein LC3 B antibody
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应用
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate)
IF: 1:50-1:500
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Fig1: Western blot analysis ofMAP LC3α/β expression in IMR-32 (A), HeLa (B) and HepG2 (C) whole cell lysates. .
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