Anti-E-Cadherin antibody
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概述
- 产品描述E-Cadherin, a member of the cadherin superfamily, is implicated as a key player in different cellular processes including development, morphology, polarity, migration and tissue integrity (1-2). E-cadherin is a glycoprotein with an extracellular domain that interacts with other E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells. Established as a tumor and metastasis suppressor, E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis (3-4). Mutations in E-cadherin are found in gastric, breast, colorectal, thyroid and ovarian cancer (5).
- 产品名称Anti-E-Cadherin antibody
- 分子量135kDa
- 种属反应性Human,Mouse
- 验证应用WB, ICC, IHC-P, IP
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20 ℃. Stable for 12 months from date of receipt
- 存储缓冲液1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Tissue culture supernatant
- 亚细胞定位Endosome, Cell junction, Cell membrane Golgi apparatus
- 其它名称
- Arc 1 antibody
- CADH1_HUMAN antibody
- Cadherin 1 antibody
more
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应用
WB: 1:1,000
ICC: 1:100
IHC-P: 1:100
IP: 1:50
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Fig1: Western blot analysis on MCF-7 cell lysate using anti-E-Cadherin.
Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-E-cadherin.
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