Anti-ABCA1 antibody
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概述
- 产品描述ABC1 (for ATP-binding cassette transporter 1) is a member of the family of ATP-binding cassette proteins which transport various molecules across biological membranes. ABC1 contains two characteristic ATP-binding domains and 12 transmembrane domains which form a channel-like structure for transport. Mutations in the ABC1 gene are implicated in Tangier disease, characterized by low serum high density lipoprotein. ABC1 is widely expressed in human tissues, with high levels of expression in liver, lung, adrenal glands, placenta and fetal tissue. ABC1 expression is induced during monocyte differentiation and upregulated in the presence of acetylated low-density lipoprotein. ABC1 may have a dual regulatory function in macrophage lipid metabolism and inflammation.
- 产品名称Anti-ABCA1 antibody
- 分子量254 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,ICC,IHC-P,FC
- 抗体类型兔多抗
- 免疫原peptide
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Peptide affinity purified
- 亚细胞定位Membrane
- 其它名称
- ABC 1 antibody
- ABC Transporter 1 antibody
- ABC-1 antibody
more
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应用
WB: 1:500-1:1,000
ICC: 1:50-1:200
IHC-P: 1:50-1:200
FC: 1:50-1:100
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Fig1: Western blot analysis on Jurkat cell lysates using anti-ABCA1 rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of PC-3M cells using anti-ABCA1 rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin- embedded human liver tissue using anti-ABCA1 rabbit polyclonal antibody
Fig4: Immunohistochemical analysis of paraffin- embedded human pancreas tissue using anti-ABCA1 rabbit polyclonal antibody.
Fig5: Immunohistochemical analysis of paraffin- embedded mouse prostate tissue using anti-ABCA1 rabbit polyclonal antibody.
Fig6: Immunohistochemical analysis of paraffin- embedded mouse pancreas tissue using anti-ABCA1 rabbit polyclonal antibody.
Fig7: Flow cytometric analysis of Jurkat cells with ABCA1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary
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