Anti-PABPC4 antibody
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概述
- 产品描述Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- 产品名称Anti-PABPC4 antibody
- 分子量71kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,ICC,IF
- 抗体类型兔多抗
- 免疫原Synthetic peptide within HumanPABPC4 aa221-320.
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1mg/ml
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Protein A purified
- 亚细胞定位Cytoplasm
- 其它名称
- Activated platelet protein 1 antibody
- Activated-platelet protein 1 antibody
- APP 1 antibody
more
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应用
WB:1:500-2000
IHC-P:1:100-500
ICC:1:100-500
IF:1:100-500
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
