Anti-P2RX7 antibody
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概述
- 产品描述The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.
- 产品名称Anti-P2RX7 antibody
- 分子量69 kDa
- 种属反应性Human,Mouse,Rat
- 验证应用WB,IHC-P,ICC
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human P2RX7:115-160/595
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/ml
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Cell membrane; Multi-pass membrane protein.
- 其它名称
- ATP receptor antibody
- P2rx7 antibody
- P2RX7_HUMAN antibody
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应用
WB: 1:500-1:2000
IHC-P: 1:50-1:200
ICC: 1:50-1:200
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
