Anti-NCK1 antibody [C2-B7]

Anti-NCK1 antibody [C2-B7]

• 概述

• 产品描述NCK1 couples tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. Specifically, overexpression of Nck1 in NIH/3T3 cells decreases DNA synthesis stimulated by EGF. Furthermore, the SH2 domain of NCK2 inhibits EGF- and PDGF-induced DNA synthesis. The SH3 domain of NCK binds a proline-rich domain on PAK, a known actin cytoskeleton regulator. The NCK protein thus mediates the interaction between PAK and RAC. The NCK2 protein binds human PDGFR-b (Tyr 1009); overexpression of Nck2 inhibits PDGF-induced membrane ruffling and lamellipod formation. Various growth factor receptors, cell surface antigens and adhesion molecules phosphorylate mammalian NCK1 and NCK2. The human NCK1 and NCK2 genes map to chromosomes 3q21 and 2q12, respectively.
• 产品名称Anti-NCK1 antibody [C2-B7]
• 分子量43 kDa
• 种属反应性Human,Monkey
• 验证应用WB,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 其它名称
  • Cytoplasmic protein NCK1 antibody
  • Melanoma Nck protein antibody
  • MGC12668 antibody
  more

• 应用

  WB: 1:500
  IHC-P: 1:50-1:200
  FC: 1:100-1:200

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  Fig1: Western blot analysis of NCK1 on human NCK1 recombinant protein using anti-NCK1 antibody at 1/1,000 dilution.

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