Anti-LRP6 antibody [1G8]

Anti-LRP6 antibody [1G8]

• 概述

• 产品描述Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRPs (low density lipoprotein related proteins), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated α-2-macroglobulin receptor, is a endocytic receptor that mediates the uptake of at least 15 ligands, including α-2-macroglobulin and ApoE. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP1 gene localizes to a potential AD locus on chromosome 12. The human LRP6 gene localizes to chromosome 12p13.2 and encodes a protein with a unique pattern of four epidermal growth factor (EGF) and three LDLR repeats in the extracellular domain. LRP6 mediates Wnt/β-catenin signaling, which controls various developmental processes, including patterning of the body axis, central nervous system and limbs, and regulation of organogenesis.
• 产品名称Anti-LRP6 antibody [1G8]
• 分子量183 kDa
• 种属反应性Human,Mouse
• 验证应用WB,IP,IF,IHC-P
• 抗体类型小鼠单抗
• 免疫原Amino acids 1314-1613 of LRP6 of human origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane, Endoplasmic reticulum
• 其它名称
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• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-1:500
  IHC-P: 1:50-1:500

•  

  

  Fig1: Western blot analysis of LRP6 expression in HeLa whole cell lysate.

   

  

  Fig2: Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing membrane and cytoplasmic staining of glandular cells.

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