Anti-CD11b/ITAM antibody [4G2]

Anti-CD11b/ITAM antibody [4G2]

• 概述

• 产品描述Integrin ?M, also designated complement component receptor-3 ?, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin ?M combines with the Integrin ∫2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin ?M/∫2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
• 产品名称Anti-CD11b/ITAM antibody [4G2]
• 分子量170kDa
• 种属反应性Human,Mouse
• 验证应用IP,IF
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane
• 其它名称
  • antigen CD11b (p170) antibody
  • Antigen CD11b p170 antibody
  • CD11 antigen like family member B antibody
  more

• 应用

  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  IF: 1:50-500
  FC: 1 μg per 1 x 106 cells

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  Fig1: Western blot analysis of Integrin αM expression in human PBL whole cell lysate immunoprecipitated with Integrin αM (2LPM19c) and detected with Integrin αM (H-61).

   

  

  Fig2: Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing membrane staining.

   

  

  Fig3: FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.

   

  

  Fig4: FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1.

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