Anti-IFN alpha R1 antibody [2G1]

Anti-IFN alpha R1 antibody [2G1]

• 概述

• 产品描述The type I interferons (IFNs), ? and ∫, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The ? and ∫ IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN?) binds to a distinct receptor. The latter protein, IFN-?R, is only weakly responsive to type I interferons in contrast to IFN-?/∫R, which binds to and responds effectively to IFN-∫ and to several of the IFN-? subtypes. Moreover, IFN-?/∫R is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-?R1 is a receptor for IFN-?/∫ and is present as the full chain (IFN-?R1a) and as a splice-variant (IFN-?R1). The IFN-? receptor complex consists of an alpha subunit (IFN-?R?) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).
• 产品名称Anti-IFN alpha R1 antibody [2G1]
• 种属反应性Mouse
• 验证应用WB,IP
• 抗体类型小鼠单抗
• 免疫原The extracellular domain of IFN-αR1 of mouse origin.
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Membrane
• 其它名称
  • Alpha type antiviral protein antibody
  • Antiviral protein, alpha-type antibody
  • Antiviral protein, beta-type antibody
  more

• 应用

  WB: 1:100-1:1,000
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  FC: 1 μg per 1 x 106 cells

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