Anti-CD80/B7-1 antibody [8-E5]

Anti-CD80/B7-1 antibody [8-E5]

• 概述

• 产品描述CD80/B7-1 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines. B7-1 is a costimulatory molecule for the activation of both CD4+ and CD8+ T lymphocytes that prevents the induction of clonal anergy. Thus, the transfer of B7-1 genes into tumor cells can induce protective immunity and lead to tumor rejection of some tumors in model systems of in vivo tumor growth.
• 产品名称Anti-CD80/B7-1 antibody [8-E5]
• 分子量60 kDa
• 种属反应性Human,Mouse
• 验证应用WB,ICC,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG2b
• 纯化方式Protein A purified.
• 亚细胞定位cell membrane
• 其它名称
  • Activation B7-1 antigen antibody
  • B lymphocyte activation antigen B7 antibody
  • B7 antibody
  more

• 应用

  WB: 1:500
  ICC: 1:100-1:200
  IHC-P: 1:50

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  Fig1: Western blot analysis on human brain tissue lysates using anti-CD80 Mouse mAb (Cat. # M1007-10)

   

  

  Fig2: Immunofluorescent staining of L929 cells using using anti-CD80 Mouse mAb (Cat. # M1007-10).

   

  

  Fig3: Immunohistochemical analysis of paraffin- embedded human brain tissue using using anti-CD80 Mouse mAb (Cat. # M1007-10).

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