Anti-TRIP6 antibody [G1-H4]

Anti-TRIP6 antibody [G1-H4]

• 概述

• 产品描述Zyxin is a LIM domain-containing, zinc finger domain-containing, SH3 ligand-containing phosphoprotein that localizes to focal adhesion plaques and actin filament bundles. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein. TRIP6 interacts with the ligand binding domain of the thyroid receptor and is predominantly expressed in kidney, liver and lung. It interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a TNF- or IL-1-dependent manner. TRIP6 also interacts with TRAF2, a protein that is crucially involved in TNF signaling, as well as the IL-1 receptor, TLR2 and Nod1. Overexpression of TRIP6 facilitates NFkappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NFkappaB activation by TNF, IL-1, TLR2 or Nod1. Moreover, TRIP6 also potentiates RIP2- and Nod1-mediated ERK activation.
• 产品名称Anti-TRIP6 antibody [G1-H4]
• 分子量50 kDa
• 种属反应性Human
• 验证应用WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Cytoplasm. Cell junction. Nucleus.
• 其它名称
  • MGC10556 antibody
  • MGC10558 antibody
  • MGC29959 antibody
  more

• 应用

  WB: 1:500
  FC: 1:100-1:200

•  

  

  Fig1: Western blot analysis of TRIP6 on human TRIP6 recombinant protein using anti-TRIP6 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of TRIP6 on K562 (1) and A431 (2) cell lysate using anti-TRIP6 antibody at 1/1,000 dilution.

   

  

  Fig3: Flow cytometric analysis of K562 cells with TRIP6 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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