Anti-FOXP2 antibody
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概述
- 产品描述The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation.
- 产品名称Anti-FOXP2 antibody
- 分子量80 kDa
- 种属反应性Human
- 验证应用WB,FC
- 抗体类型小鼠单抗
- 免疫原Recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位Nucleus.
- 其它名称
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应用
WB: 1:500-1:2,000
FC: 1:100-1:200
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Fig1: Western blot analysis of FOXP2 on human FOXP2 recombinant protein using anti-FOXP2 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of FOXP2 on HEK293 (1) and FOXP2-hIgGFc transfected HEK293 (2) cell lysate using anti-FOXP2 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of FOXP2 on HepG2 cell lysate using anti-FOXP2 antibody at 1/1,000 dilution.
Fig4: Flow cytometric analysis of Hela cells with FOXP2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
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