Anti-ALDH2 antibody [7-D8]

Anti-ALDH2 antibody [7-D8]

• 概述

• 产品描述Aldehyde dehydrogenase 2 family (mitochondrial), also known as ALDH2, is a human gene found on chromosome 12. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. The ALDH2 gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Most Europeans have two major isozymes, while approximately 50% of Northeast Asians have one normal copy of the ALDH2 gene and one mutant copy that encodes an inactive mitochondrial isoenzyme. A remarkably higher frequency of acute alcohol intoxication among Northeast Asians than among Europeans has been repeatedly shown to be related to the very much reduced activity of the mutant ALDH2-2 isoenzyme.
• 产品名称Anti-ALDH2 antibody [7-D8]
• 分子量56 kDa
• 种属反应性Human
• 验证应用WB,ICC,IHC-P
• 抗体类型小鼠单抗
• 免疫原peptide
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Mitochondrion matrix
• 其它名称
  • Acetaldehyde dehydrogenase 2 antibody
  • Aldehyde dehydrogenase 2 family (mitochondrial) antibody
  • Aldehyde dehydrogenase 2 family antibody
  more

• 应用

  WB: 1:2,000
  ICC: 1:100-1:200
  IHC-P: 1:200-1:500

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  Fig1: Western blot analysis on HepG2 cell lysates using anti- ALDH2 mouse mAb.

   

  

  Fig2: ICC staining ALDH2 in HepG2 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti- ALDH2 mouse mAb.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- ALDH2 mou

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