Anti-CYP27B1 antibody
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概述
- 产品描述The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP27B1, a 508-amino acid protein that belongs to the XXVIIB subfamily of the cytochrome P450 family, localizes to the mitochondrion and is expressed in the kidney. The CYP27B1 protein catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) and functions in calcium metabolism, normal bone growth, and tissue differentiation. Mutations in the gene which encodes for CYP27B1 cause vitamin D-dependent rickets type 1 (VDDR-1), also designated pseudovitamin D deficiency rickets (PDDR), an autosomal recessive disease characterized by early onset of rickets with hypocalcemia and muscle weakness.
- 产品名称Anti-CYP27B1 antibody
- 分子量57 KDa
- 种属反应性Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human CYP27B1 1-100/508
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Mitochondrion membrane.
- 其它名称
- 1alpha(OH)ase
25-hydroxyvitamin D(3) 1-alpha-hydroxylase
25-hydroxyvitamin D-1 alpha hydroxylase
25-OHD-1 alpha-hydroxylase
Calcidiol 1-monooxygenase
CP27B_HUMAN
CP2B
CYP1
CYP1ALPHA
CYP27B
Cyp27b1
Cytochrome p450 27B1
Cytochrome p450 27B13
Cytochrome P450 family 27 subfamily B polypeptide 1
Cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1
Cytochrome P450 subfamily XXVIIB polypeptide 1
Cytochrome P450C1 alpha
Cytochrome P450VD1-alpha
mitochondrial
P450C1 alpha
P450c1
P450C1-alpha
P450VD1-alpha
PDDR
VD3 1A hydroxylase
VDD1
VDDR
VDDR I
VDDRI
VDR.
more
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Fig1: Sample:Kidney (Mouse) Lysate at 40 ug
Primary: Anti- CYP27B1at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution.
Predicted band size: 57kD
Observed band size: 57kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
