Anti-CHRNB2 antibody
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概述
- 产品描述Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene. Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.
- 产品名称Anti-CHRNB2 antibody
- 分子量52 KDa
- 种属反应性Human,Mouse,Rat,Chicken,Dog,Pig,Cow
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human CHRNB2 131-230/502
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式Affinity purified by Protein A
- 亚细胞定位Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
- 其它名称Nicotinic Acetylcholine Receptor beta 2
Acetylcholine receptor beta 2 neural
ACHB2_HUMAN
ACHN
Acrb 2
Acrb2
b2 nAchR
Cholinergic receptor nicotinic beta 2
Cholinergic receptor nicotinic beta polypeptide 2
Cholinergic receptor nicotinic beta polypeptide 2 neuronal
CHRNB2
EFNL 3
EFNL3
nAChRB2
Neuronal acetylcholine receptor protein beta 2 chain precursor
Neuronal acetylcholine receptor protein subunit beta 2
Neuronal acetylcholine receptor subunit beta-2
Neuronal nicotinic acetylcholine receptor beta 2.
more
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Fig1: Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebellum (Mouse) Lysate at 40 ug
Cerebral cortex (Mouse) Lysate at 40 ug
Cerebrum (Rat) Lysate at 40 ug
Primary: Anti-CHRNB2 at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 52 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
