Anti-PPP1R10 antibody
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概述
- 产品描述PPP1R10 (serine/threonine protein phosphatase 1 regulatory subunit 10), also known as PNUTS, is a targeting subunit of protein phosphatase 1 (PP1). Furthermore, PPP1R10 acts as an inhibitor of PPP1CA and PPP1CC phosphatase activities. Its inhibitory activity on PPP1CA is only observed when PPP1R10 is phosphorylated by Protein Kinase A (PKA). PPP1R10 contains a zinc finger motif and is predominantly localised within the nucleus. Recently, PPP1R10 has been shown to target PP1 to GABA(C) receptors, shuttling from the nucleus to the cell membrane in cells co-expressing this receptor. This highlights a role for this protein in the regulation of synaptic signal transduction. PPP1R10 has also been shown to regulate the activity of p53 in response to hypoxia.
- 产品名称Anti-PPP1R10 antibody
- 分子量99 KDa
- 种属反应性Human,Mouse,Rat,Dog,Pig,Cow,Sheep
- 验证应用WB
- 抗体类型兔多抗
- 免疫原KLH conjugated synthetic peptide derived from human PPP1R10 151-250/940
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度1 mg/mL.
- 存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
- 存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 亚型IgG
- 纯化方式affinity purified by Protein A
- 亚细胞定位Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase
- 其它名称PNUTS
CAT 53
CAT53
FB 19
FB19
FB19 protein
MHC class I region proline rich protein CAT53
p99
Phosphatase 1 nuclear targeting subunit
Phosphatase nuclear targeting subunit
PNUTS
PP1 binding protein of 114 kDa
PP1R10
Protein phosphatase 1 regulatory (inhibitor) subunit 10
Protein phosphatase 1 regulatory subunit 10
Serine/threonine protein phosphatase 1 regulatory subunit 10
PP1RA_HUMAN.
more
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Fig1: Sample:
Spleen (Mouse) Lysate at 40 ug
Primary: Anti-PPP1R10 at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 99 kD
Observed band size: 99 kD
特别提示：本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
