Anti-STAT6 antibody

Anti-STAT6 antibody

• 概述

• 产品描述In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.

• 产品名称Anti-STAT6 antibody

• 分子量94 kDa

• 种属反应性Human

• 验证应用WB,ICC,IHC-P,FC

• 抗体类型兔多抗

• 免疫原peptide

• 偶联Non-conjugated

• 性能

• 形态Liquid

• 浓度1 mg/mL.

• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

• 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• 亚型IgG

• 纯化方式Peptide affinity purified

• 亚细胞定位Cytoplasm, nucleus.

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• ​其它名称12S1644 antibody
  D12S1644 antibody
  IL 4 STAT antibody
  IL-4 Stat antibody
  IL4 STAT antibody
  Interleukin 4 Induced antibody
  Interleukin 4 Induced Transcription Factor IL4 STAT antibody
  Signal transducer and activator of transcription 6 antibody
  Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody
  Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody
  Signal transducer and activator of transcription 6, interleukin 4 induced antibody
  STAT 6 antibody
  STAT interleukin4 induced antibody
  STAT, interleukin4 induced antibody
  Stat6 antibody
  STAT6_HUMAN antibody
  STAT6B antibody
  STAT6C antibody
  Transcription factor IL 4 STAT antibody

  more

• 应用

  WB: 1:1,000
  ICC: 1:200
  IHC-P: 1:200
  FC: 1:100-1:200

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  Fig1: Western blot analysis of STAT6 on different cell lysates using anti-STAT6 antibody at 1/1000 dilution.
  Positive control:
  Lane 1: Raji
  Lane 2: Daudi
  Lane 3: Hela
  Lane 4: Ags
  Lane 5: Jurkat

   

  

  Fig2: ICC staining STAT6 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-STAT6 antibody. Counter stained with hematoxylin.

   

  

  Fig4: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-STAT6 antibody. Counter stained with hematoxylin.

   

  

  Fig5: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-STAT6 antibody. Counter stained with hematoxylin.

   

  

  Fig6: Flow cytometric analysis of Hela cells with ATAT6 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Goat anti rabbit IgG (FITC) was used as the secondary antibody.

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