Anti-GFR2/CD332 antibody
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概述
- 产品描述Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 has two naturally occurring isoforms FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in ectoderm derived tissues and endothelial organ lining, i.e. skin and internal organs. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the Fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. As mentioned, FGFR2 mutations are associated with craniosynostosis syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself.
- 产品名称Anti-FGFR2/CD332 antibody
- 分子量150 kDa
- 种属反应性Human,Mouse
- 验证应用WB,ICC,IHC-P
- 抗体类型小鼠单抗
- 免疫原recombinant protein
- 偶联Non-conjugated
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性能
- 形态Liquid
- 浓度2 mg/mL.
- 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
- 存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- 亚型IgG1
- 纯化方式Protein A purified.
- 亚细胞定位Cell membrane
- 其它名称
- bacteria-expressed kinase antibody
- BBDS antibody
- BEK antibody
more
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应用
WB: 1:500
ICC: 1:100-1:200
IHC-P: 1:100-1:200
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Fig1: Western blot analysis of FGFR2 on different cell lysates using anti-FGFR2 antibody at 1/500 dilution.
Positive control:
Lane 1: MCF-7
Lane 2: K562
Lane 3: Hela
Lane 4: HepG2
Lane 5: A431
Lane 6: A549
Lane 7: NIH/3T3
Lane 8: Jurkat
Lane 9: Mouse brain
Fig2: ICC staining of FGFR2 in MCF-7 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining of FGFR2 in Ags cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig4: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FGFR2 antibody. Counter stained with hematoxylin.
Fig5: Immunohistochemical analysis of paraffin-embedded human stomach carcinoma tissue using anti-FGFR2 antibody. Counter stained with hematoxylin.
Fig6: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-FGFR2 antibody. Counter stained with hematoxylin
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