Anti-SCGB2A2 antibody [E2-C80]

Anti-SCGB2A2 antibody [E2-C80]

• 概述

• 产品描述Secretoglobins (also called lipophilins or mammaglobins) are small secreted proteins of endocrine-responsive organs and mucosal epithelia that form multimeric complexes and correlate with the development of various human cancers. Lipophilin A and Lipophilin B are orthologs of prostatein (estramustine-binding protein), the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin A, also designated LIPA, LPHA and secretoglobin, family 1D, member 1 (SCGB1D1), is a component of a heterodimeric molecule present in human tears. Lipophilin B, also designated LIPB, LPHB and secretoglobin, family 1D, member 2 (SCGB1D2), mRNA can be overexpressed in breast tumors and shows a high degree of correlation with the mRNA expression profile of mammaglobin. Histological detection in breast tissue of Mammaglobin A, also designated MGB1 and secretoglobin, family 2A, member 2 (SCGB2A2) and Mammaglobin B (also designated MGB2, lipophilin C, LPHC, UGB3 and SCGB2A2) is a reliable diagnostic marker for breast tumors.
• 产品名称Anti-SCGB2A2 antibody [E2-C80]
• 分子量11 kDa
• 种属反应性Human
• 验证应用WB,ICC,IHC-P,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • Mammaglobin 1 antibody
  • Mammaglobin-1 antibody
  • Mammaglobin-A antibody
  more

• 应用

  WB: 1:500-1:1,000
  ICC: 1:50-1:200
  IHC-P: 1:50-1:200
  FC: 1:100-1:200

•  

  

  Fig1: Western blot analysis of Mammaglobin A on human Mammaglobin A recombinant protein using anti- Mammaglobin A antibody at 1/1,000 dilution.

   

  

  Fig2: ICC staining Mammaglobin A (green) and actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

   

  

  Fig3: Immunohistochemical analysis of paraffin-embedded human mammary cancer tissue using anti- Mammaglobin A antibody. Counter stained with hematoxylin.

   

  

  Fig4: Flow cytometric analysis of SK-BR-3 cells with Mammaglobin A antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).

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