Anti-ADAMTS1 antibody [E6-C12]

Anti-ADAMTS1 antibody [E6-C12]

• 概述

• 产品描述ADAMTS-1, also known as METH-1, C3-C5 and KIAA1346, and the related protein ADAMTS-8, also known as METH-2 and FLJ41712, represent a new family of proteins with metalloprotease, disintegrin and Thrombospondin domains. ADAMTS-1 and ADAMTS-2 are secreted and proteolytically processed proteins that are 51.7% identical but display different, non-overlapping patterns of expression in tissues and cultured celllines. Both ADAMTS proteins have been shown to be more active than Thrombospondin-1 or endostatin in preventing angiogenesis in a cornea pocket model, and both may have application for the inhibition of new blood vessel formation in a range of tumor types. The spacer region and the Thrombospondin type I motifs in the carboxy-terminus of ADAMTS-1 are important for anchoring ADAMTS-1 to the extracellular matrix.
• 产品名称Anti-ADAMTS1 antibody [E6-C12]
• 分子量80 kDa
• 种属反应性Human
• 验证应用WB,FC
• 抗体类型小鼠单抗
• 免疫原Recombinant protein
• 偶联Non-conjugated

• 性能

• 形态Liquid
• 浓度2 mg/mL.
• 存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
• 存储缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• 亚型IgG1
• 纯化方式Protein A purified.
• 亚细胞定位Secreted.
• 其它名称
  • A disintegrin and metalloproteinase with thrombospondin motifs 1 antibody
  • ADAM-TS 1 antibody
  • ADAM-TS1 antibody
  more

• 应用

  WB: 1:500
  FC: 1:50-1:100

•  

  

  Fig1: Western blot analysis of ADAMTS1 on human ADAMTS1 recombinant protein using anti-ADAMTS1 antibody at 1/1,000 dilution.

   

  

  Fig2: Western blot analysis of ADAMTS1 on HEK293 (1) and ADAMTS1-hIgGFc transfected HEK293 (2) cell lysate using anti-ADAMTS1 antibody at 1/1,000 dilution.

   

  

  Fig3: Western blot analysis of ADAMTS1 on Hela cell lysate using anti-ADAMTS1 antibody at 1/1,000 dilution.

   

  

  Fig4: Flow cytometric analysis of Hela cells with ADAMTS1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

   

  

  Fig5: Flow cytometric analysis of K562 cells with ADAMTS1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

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