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ClinMax™Human Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) Quantitative ELISA Kit
ClinMax™Human GM-CSF Quantitative ELISA Kit is designed to quantitate human GM-CSF that is present in complex biological matrices, such as human serum, plasma, buffered solution, or cell culture. GM-CSF is a colony-stimulating factor that regulates growth and differentiation of hematopoietic cells. GM-CSF is a primarily T cell-derived 14-35 kDa variably glycosylated protein which affects growth and functions of granulocytes and cells of the macrophage lineage at all stages of maturation. It is also required for the development of specialized alveolar macrophages responsible for pathogen surveillance and the metabolism of pulmonary surfactant. Its production is widespread throughout the body in certain infectious and inflammatory states to enhance a local innate immune response. On the other hand, its abnormal production can lead to chronic inflammatory states as observed in rheumatoid arthritis and asthma. Some of the actions of GM-CSF include enhancing macrophage, neutrophil, eosinophil, and natural killer cell effector functions; dendritic cell survival and differentiation; and the up-regulation of antigen presentation.
This immunoassay is designed to quantitate human GM-CSF that is present in human serum, plasma, buffered solution, or cell culture. It has been calibrated against a highly purified human GM-CSF and is evaluated with standard from NIBSC/WHO. Reference Reagent GM-CSF (Human, rDNA derived) NIBSC code: 88/646.
It is for research use only.
The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
